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The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways

✍ Scribed by T. Kataoka; R.C. Budd; N. Holler; M. Thome; F. Martinon; M. Irmler; K. Burns; M. Hahne; N. Kennedy; M. Kovacsovics; J. Tschopp


Book ID
114317685
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
215 KB
Volume
10
Category
Article
ISSN
0960-9822

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## Abstract Effective stimulation of NF‐κB in T cells following TCR ligation requires the activity of caspase‐8. The active caspase‐8 complex includes the paracaspase, MALT1, and Bcl‐10, which connect to the NF‐κB pathway. It has been less clear what regulates the level of caspase‐8 activity during