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The carcinogenic effect of 1,1-diethyl-3-methyl-3-nitrosourea in European hamsters

✍ Scribed by Ketkar, M.B.; Althoff, J.; Lijinsky, W.

Book ID
122519099
Publisher
Elsevier
Year
1981
Tongue
English
Weight
302 KB
Volume
20
Category
Article
ISSN
0232-1513

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The physiologic disposition of radioactive-labelled CCNU and MeCCNU was studied in patients receiving these drugs as part of their early clinical trial. CCNU was given orally in doses of 30-100 mg/m2 a n d MeCCNU in doses of 120-290 mg/m?. With both drugs, significant plasma levels of radioactivity