The carbonyl insertion reactions of mixed tervalent phosphorus-organosilicon reagents

✍ Scribed by D.A. Evans; K.M. Hurst; L.K. Truesdale; J.M. Takacs

• Book ID: 104236055
• Publisher: Elsevier Science
• Year: 1977
• Tongue: French
• Weight: 233 KB
• Volume: 18
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)83802-8

✦ Synopsis

In conjunction with our general interest in the development of synthetic operations which reverse the normal polar reactivity patterns of the carbonyl function, 1 we have been focusing our attention on carbonyl derivatives which could serve as operational equivalents to the hypothetical carbanions 1 and 2. 2,3 In this regard we have been engaged in the development of organosilicon reagents 2 containing potential carbanion-stabilizing functions, A, which will undergo facile carbonyl addition (eq. 1). In principle, such carbonyl derivatives, upon metalation, should serve as valuable carbon nucleophi.les in organic synthesis. During the