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The calpain-calpastatin system in mammalian cells: properties and possible functions

✍ Scribed by E. Melloni; F. Salamino; B. Sparatore

Book ID: 119161037
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 563 KB
Volume: 74
Category: Article
ISSN: 0300-9084
DOI: 10.1016/0300-9084(92)90120-4

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Calpains have importance in human neurodegenerative disease pathogenesis, but these mechanisms are difficult to study in postmortem tissues. To establish a cellular model of the human calpain and calpastatin system, we characterized calpain I, calpain II, and calpastatin in SH-SY5Y human neuroblasto