✍ Scribed by Eran Hornstein; Nissim Benvenisty
No coin nor oath required. For personal study only.
The recent isolation of human embryonic stem (ES) cells is evoking great hopes for their future utilization in cell‐replacement therapies and human development research. The hallmarks of ES cells, pluripotency and self‐renewal capacity, suggest an infinite source for tissues of virtually all desired types. Specifically, human ES cells may potentially be the basis for effective treatments of a wide range of human neurodegenerative disorders. To enable the translation of this novel biomedical field into the clinic, mechanisms that control the differentiation of human embryonic stem cells into fully functional neuronal cells should be analyzed and controlled. © 2004 Wiley‐Liss, Inc.
📜 SIMILAR VOLUMES
## Abstract Availability of human embryonic stem cells (hESC) has enhanced human neural differentiation research. The derivation of neural progenitor (NP) cells from hESC facilitates the interrogation of human embryonic development through the generation of neuronal subtypes and supporting glial ce
## Abstract Induced pluripotent stem cell (iPSC) technology has emerged as the most promising method for generating patient‐specific human embryonic stem (ES) cells and adult stem cells (Takahashi et al., 2007, Cell 131:861–872; Wernig et al., 2007, Nature 448:318–324; Park et al., 2008, Nature 451
## Abstract Human embryonic stem (HES) cells are pluripotent and give rise to any cell lineage. More specifically, how the first embryonic lineage (i.e., cardiac lineage) is acquired remains in many aspects questionable. Herein, we summarize the protocols that have been used to direct the fate of H