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The bortezomib-induced mitochondrial damage is mediated by accumulation of active protein kinase C-δ

✍ Scribed by David Durrant; Jihua Liu; Hung-Sheng Yang; Ray M. Lee


Book ID
116288957
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
388 KB
Volume
321
Category
Article
ISSN
0006-291X

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## Abstract Phospholipid scramblase 3 (PLS3) is a member of the phospholipid scramblase family present in mitochondria. PLS3 plays an important role in regulation of mitochondrial morphology, respiratory function, and apoptotic responses. PLS3 is phosphorylated by PKC‐δ at Thr21 and is the mitochon