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The blood picture of normal laboratory animals. A Review of the literature, 1936–1946

✍ Scribed by Mary Virginia Gardner

Publisher
Elsevier Science
Year
1947
Tongue
English
Weight
532 KB
Volume
243
Category
Article
ISSN
0016-0032

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✦ Synopsis

The literature prior to 1926 on blood studies of normal animals was reviewed by Scarborough (1). The development of new and more accurate methods for the determination and enumeration of the blood elements suggested the importance of reviewing the literature for the past decade. This review lays no claim to being exhaustive, but it brings up to date the standards of comparison for hematological work on laboratory animals which Scarborough so effectively provided twenty years ago.

Most of the values recorded here were those obtained from normal animals used as controls in the experimental work reported by the authors. For that reason the number of animals recorded is often small and sometimes the range of normal values is given rather than the mean. The species or strain used has been indicated where possible.

TI-IE RAT.

Method of Obtaining Blood.--Blood is usually obtained from the tail, either by clipping the end of the tail or incising the vein, or by cardiac puncture.

Red Blood Cells.--The red blood cell of the rat is a biconcave disc which varies little in shape. In Vqright-stained preparations the eryth-TABLE I. Reticulocytes. Age new-born new-born 1 day Average 4 days 5-25 days 3-4 months adult adult adult adult adult adult

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THE GUINEA PIG, Guinea pigs are no longer the most commonly used laboratoryanimal as they probably were before 1930, when Scarborough (1) reviewed the literature on the blood picture of normal guinea pigs. For that reason fewer reports on guinea pig hematology have been appearing in the literature,