The Biosynthesis of Barbamide—A Radical Pathway for “Biohalogenation”?

✍ Scribed by Jens Hartung

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 81 KB
• Volume: 38
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/(sici)1521-3773(19990503)38:9<1209::aid-anie1209>3.0.co;2-f

✦ Synopsis

A stereoselective chlorination of a methyl group and the preference of cleavage of nonactivated primary C-H bonds in one of the methyl groups with respect to a weaker tertiary C-H bond in the course of the biosynthesis of barbamide point to a surprising, new mechanism of "biohalogenation" (see schematic diagram).