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The biosynthesis of [5′-14C]cotinine and other radiolabeled nicotine metabolites

✍ Scribed by Mui-Chiung Tsai; Yang Sai; Yan Li; George Aislaitner; John W. Gorrod

Publisher
John Wiley and Sons
Year
1999
Tongue
French
Weight
617 KB
Volume
42
Category
Article
ISSN
0022-2135

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✍ Mark K. Shigenaga; Peyton Jacob; Anthony Trevor; Neal Castagnoli Jr.; Neal Benow 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 499 KB

The synthesis of high specific activity tritium labeled (S)-nicotine and (S)-cotinine has been achieved. ( S ) - 5-Bromonornicotine of high enantiomeric purity was converted to the corresponding (S) -5-bromonicotine by reductive amination with formaldehyde and sodium borohydride. Tritidysis of this