The biology of the mammalian Krüppel-like family of transcription factors
✍ Scribed by Duyen T. Dang; Jonathan Pevsner; Vincent W. Yang
- Book ID
- 117755612
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 137 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1357-2725
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KLF3 is a member of the Kru ¨ppel-like factor (KLF) family of transcription factors. These proteins are classified by the presence of three C-terminal C2H2 zinc fingers that allow sequence-specific binding to CACCC boxes and GC-rich motifs found in the promoters, enhancers, and other control regions
An essential role for the Kru ¨ppel-like transcription factor family has been determined in the regulation of remarkable processes including cell proliferation, differentiation, signal transduction, oncogenesis, and cell death. A member of this group, Kru ¨ppel-like factor 6 (KLF6), identified on th
## Abstract The Sp/KLF family contains at least twenty identified members which include Sp1‐4 and numerous krüppel‐like factors. Members of the family bind with varying affinities to sequences designated as ‘Sp1 sites’ (e.g., GC‐boxes, CACCC‐boxes, and basic transcription elements). Family members