Krüppel-like transcription factors: A functional family
✍ Scribed by Richard Pearson; Jacqueline Fleetwood; Sally Eaton; Merlin Crossley; Shisan Bao
- Book ID
- 116307454
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 182 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1357-2725
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## Abstract The Sp/KLF family contains at least twenty identified members which include Sp1‐4 and numerous krüppel‐like factors. Members of the family bind with varying affinities to sequences designated as ‘Sp1 sites’ (e.g., GC‐boxes, CACCC‐boxes, and basic transcription elements). Family members
KLF3 is a member of the Kru ¨ppel-like factor (KLF) family of transcription factors. These proteins are classified by the presence of three C-terminal C2H2 zinc fingers that allow sequence-specific binding to CACCC boxes and GC-rich motifs found in the promoters, enhancers, and other control regions