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The biology of myeloid-derived suppressor cells: The blessing and the curse of morphological and functional heterogeneity

✍ Scribed by Je-In Youn; Dmitry I. Gabrilovich

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
264 KB
Volume
40
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

Myeloid‐derived suppressor cells (MDSC) play an important role in the cellular network regulating immune responses in cancer, chronic infectious diseases, autoimmunity, and in other pathological conditions. Morphological, phenotypic and functional heterogeneity is a hallmark of MDSC. This heterogeneity demonstrates the plasticity of this immune suppressive myeloid compartment, and shows how various tumors and infectious agents can have similar biological effects on myeloid cells despite the differences in the factors that they produce to influence the immune system; however, such a heterogeneity creates ambiguity in the definition of MDSC as well as confusion regarding the origin and fate of these cells. In this review, we will discuss recent findings that help to better clarify these issues and to determine the place of MDSC within the myeloid cell lineage.

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