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The biology of IL-12: coordinating innate and adaptive immune responses

✍ Scribed by Wendy T Watford; Masato Moriguchi; Akio Morinobu; John J O’Shea


Book ID
117757721
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
259 KB
Volume
14
Category
Article
ISSN
1359-6101

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We have investigated the importance of endogenously produced IL-12 in innate and adaptive immunity to tumor transplants. The immunogenic lymphoma RMA and its TAP-deficient variant RMA-S were tested for rejection responses by normal and IL-12-deficient mice. IL-12 was crucial for the immunity induced