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IL-12 and IL-23: master regulators of innate and adaptive immunity

✍ Scribed by Claire L. Langrish; Brent S. McKenzie; Nicholas J. Wilson; Rene De Waal Malefyt; Robert A. Kastelein; Daniel J. Cua


Book ID
110746558
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
670 KB
Volume
202
Category
Article
ISSN
0105-2896

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We have investigated the importance of endogenously produced IL-12 in innate and adaptive immunity to tumor transplants. The immunogenic lymphoma RMA and its TAP-deficient variant RMA-S were tested for rejection responses by normal and IL-12-deficient mice. IL-12 was crucial for the immunity induced