Contribution of CD8+ T cells to innate immunity: IFN-γ secretion induced by IL-12 and IL-18
✍ Scribed by Rance E. Berg; Christoph J. Cordes; James Forman
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 297 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
IL-12 activates TYK2 and Janus kinase (JAK)-2 to induce the phosphorylation of various signal transducers and activators of transcription (STAT) proteins. However, little is known regarding how these JAK exhibit the distinct biological effects of IL-12. Using two JAK inhibitors, tyrphostin A1 (A1) f
## Abstract Interleukin‐12 (IL‐12) is a disulfide‐linked p40‐p35 heterodimeric cytokine and plays a key role in linking innate cellular immunity to an adaptive Th1 response against pathogens and tumor cells and in counteracting a Th2 immune response. The pathogenesis of Hodgkin's disease (HD) is pa