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The biocompatibility of silver-containing Na2O·CaO·2SiO2 glass prepared by sol–gel method: In vitro studies

✍ Scribed by Maria Grazia Raucci; Kehinde Adesanya; Lucy Di Silvio; Michelina Catauro; Luigi Ambrosio

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
828 KB
Volume
92B
Category
Article
ISSN
1552-4973

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✦ Synopsis

Abstract

This study was performed to determine the in vitro biocompatibility of a bioactive, antibacterial silver based gel. A human osteoblast‐like cell line (HOS TE85) was used to test cytocompatibility in the presence of eluants and the biological response in direct contact with Na~2~O·CaO·2SiO~2~ gel (containing 0.5050 wt % Ag~2~O prepared by a sol–gel process) sterilized by two different methods; autoclave and γ‐irradiation. MTT assay was used for the indirect evaluation of eluant toxicity and alamar Blue™ was performed to assess the biological response, which included cell viability and proliferation, and the results showed that these materials were cytocompatible. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2010

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