Bioactivity of gel-glass powders in the CaO-SiO2 system: A comparison with ternary (CaO-P2P5-SiO2) and quaternary glasses (SiO2-CaO-P2O5-Na2O)

✍ Scribed by Saravanapavan, Priya ;Jones, Julian R. ;Pryce, Russell S. ;Hench, Larry L.

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 191 KB
• Volume: 66A
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.a.10532

✦ Synopsis

Abstract

Bioactive glasses react chemically with body fluids in a manner that is compatible with the repair processes of the tissues. This results in the formation of an interfacial bond between the glasses and living tissue. Bioactive glasses also stimulate bone–cell proliferation. This behavior is dependent on the chemical composition as well as the surface texture of the glasses. It has been recently reported that gel‐derived monolith specimens in the binary SiO~2~ CaO are bioactive over a similar molar range of SiO~2~ content as the previously studied ternary CaO‐P~2~O~5~‐SiO~2~ system. In this report, the preparation and bioactivity of the binary gel–glass powder with 70 mol % SiO~2~ is discussed and its bioactivity is compared with the melt‐derived 45S5 (quaternary) Bioglass® and sol–gel‐derived 58S (ternary) bioactive gel–glass compositions. Dissolution kinetic parameters K~1~ and K~2~ were also computed based on the silicon release for all glass powders. It was shown that the simple two‐component SiO~2~‐CaO gel–glass powder is bioactive with comparable dissolution rates as the clinically used melt‐derived 45S5 Bioglass® powder and extensively studied sol–gel‐derived 58S gel–glass powder. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 66A: 110–119, 2003