The bioavailability in man of marketed brands of chlorpropamide
โ Scribed by A. M. Monro; P. G. Welling
- Publisher
- Springer
- Year
- 1974
- Tongue
- English
- Weight
- 287 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0031-6970
No coin nor oath required. For personal study only.
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## Abstract Fourteen normal male subjects were given either 60 mg or 180mg of terfenadine suspension in a randomized twoโway crossover study. Peak plasma concentrations of 1.544 ยฑ 0.726 (mean ยฑ S.D.) ng ml^โ1^ were obtained in 0.786 ยฑ 0.426 h following the 60 mg dose and displayed an AUC of 11.864
Ten healthy male volunteers received single oral doses of l00mg of medroxalol administered as a solution, a preliminary tablet formulation and a single dose of lOOmg administered intravenously in a randomized three-way crossover study. Mean terminal half-lives of 12.4, 13.4, and 11.3 h were observed