✦ LIBER ✦

Bioavailability of medroxalol in man

✍ Scribed by Frederick J. Keeley; Daniel L. Weiner; Richard A. Okerholm

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 226 KB
Volume: 4
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510040402

No coin nor oath required. For personal study only.

✦ Synopsis

Ten healthy male volunteers received single oral doses of l00mg of medroxalol administered as a solution, a preliminary tablet formulation and a single dose of lOOmg administered intravenously in a randomized three-way crossover study. Mean terminal half-lives of 12.4, 13.4, and 11.3 h were observed for the intravenous, solution and tablet formulation, respectively.

Mean urinary recovery of parent drug at 48 h was 8.9 per cent, 3.9 per cent, and 3.2 per cent. Absolute bioavailability estimated from plasma AUC was 54 per cent for the solution and 38 per cent for the tablet, and the relative bioavailability from the tablet was 71 per cent.

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