The Bioavailability and Nonlinear Clearance of (–)-Carbovir in the Rat
✍ Scribed by Shu-hui Huang; Rory P. Remmel; Cheryl L. Zimmerman
- Book ID
- 110341823
- Publisher
- Springer US
- Year
- 1991
- Tongue
- English
- Weight
- 901 KB
- Volume
- 08
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
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Bioavailability of low (10 mg/kg) and high (50 mg/kg) doses of methylprednisolone was determined after oral administration of the free alcohol of methylprednisolone and iv administration of methylprednisolone sodium succinate. Plasma concentrations of methylprednisolone and methylprednisone (reversi
Studies were designed to allow an in vivo estimation of the hepatic extraction ratio and to test the hypothesis that the pharmacokinetic parameters of (-)-CBV are significantly different during anesthesia. (-)-CBV was administered as an IV bolus followed by IV infusion into either the portal (n = 3)