The binding of [3H]thienyl cyclohexylpiperidine ([3H]TCP) to the NDDA-phencyclidine receptor complex
โ Scribed by J.M. Stirling; A.J. Cross; A.R. Green
- Book ID
- 118956074
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 757 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0028-3908
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๐ SIMILAR VOLUMES
## 4-Fluoro -l-[l-(2-thienyl)-3-cyclohexenyl)lpiperidine was efficiently synthesized in four steps starting from cyclohexane-1,4-dione monoethylene ketal. Catalytic tritiation of this key intermediate in the final step afforded the title compound.
The phencyclidine (PCP) derivative N-[l-(2-thienyl) cyclohexyl]-piperidine (3H-TCP) was used to label in vivo the N-methyl-D-aspartate (NMDA) receptor-associated ionic channel in the mouse brain. After the injection of a tracer dose of 3H-TCP, a spread labeling throughout the brain was observed, but