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The Binding Energetics of First- and Second-Generation HIV-1 Protease Inhibitors: Implications for Drug Design

✍ Scribed by Adrian Velazquez-Campoy; Yoshiaki Kiso; Ernesto Freire


Book ID
115568733
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
173 KB
Volume
390
Category
Article
ISSN
0003-9861

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## Abstract To test the anticorrelated relationship that was recently displayed in conventional molecular dynamics (MD) simulations, several different restrained MD simulations on a wild type and on the V82F/I84V drug‐resistant mutant of HIV‐1 protease were performed. This anticorrelated relationsh