The effect of inhibitor binding on the s
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Matthew J. Todd; Ernesto Freire
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Article
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1999
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John Wiley and Sons
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English
โ 337 KB
๐ 2 views
The effects of the peptide inhibitor acetyl pepstatin on the structural stability of the HIV-1 protease have been measured by high sensitivity calorimetric techniques. At 25ยฐC and pH 3.6, acetyl pepstatin binds to HIV-1 protease with an affinity of 1.6 ุ 10 7 M -1 and an enthalpy of 7.3 ุ 0.5 kcal/m