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On the correlation between drug-resistant pattern of HIV-1 protease inhibitors and binding free energy and structural changes

โœ Scribed by Kitiyaporn Wittayanarakul; Supot Hannongbua; Michael Feig


Book ID
115023535
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
183 KB
Volume
1
Category
Article
ISSN
1752-0509

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The effect of inhibitor binding on the s
โœ Matthew J. Todd; Ernesto Freire ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 337 KB ๐Ÿ‘ 2 views

The effects of the peptide inhibitor acetyl pepstatin on the structural stability of the HIV-1 protease have been measured by high sensitivity calorimetric techniques. At 25ยฐC and pH 3.6, acetyl pepstatin binds to HIV-1 protease with an affinity of 1.6 ุ‹ 10 7 M -1 and an enthalpy of 7.3 ุŽ 0.5 kcal/m