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The benzoylation of uracil and thymine

✍ Scribed by Kenneth A. Cruickshank; Josef Jiricny; Colin B. Reese


Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
265 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis


Uracil and thymine react with bensoyl chloride in acetonitrile-pyridine solution at room temperature to give first their 1-N-benzoyl (2b and 3b) and then their l-E, 3-E-dibensoyl derivatives (4a and s, respectively); <he lattercompounds are converted into the corresponding 3-E-bensoy derivatives (5a and 6a) under mild conditions of basic hydrolysis.


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