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The behavior of α-synuclein in neurons

✍ Scribed by Doris L. Fortin; Venu M. Nemani; Ken Nakamura; Robert H. Edwards

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
132 KB
Volume
25
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Despite considerable evidence linking α‐synuclein with membranes in vitro, it has proven difficult to demonstrate membrane association of the protein in vivo. α‐Synuclein localizes to the nerve terminal, but biochemical experiments have not revealed a tight association with membranes. To address the dynamics of the protein in live cells, we have used photobleaching and found that α‐synuclein exhibits high mobility, although distinctly less than an entirely soluble protein. Further, neural activity controls the distribution of α‐synuclein, causing its dispersion from the synapse. In addition to the presumed role of α‐synuclein dynamics in synaptic function, changes in its physiological behavior may underlie the pathological changes associated with Parkinson's disease. © 2010 Movement Disorder Society

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