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The Bcl-2 family of proteins and activation of the ICE-CED-3 family of proteases: A balancing act in apoptosis?

✍ Scribed by Kumar, Sharad

Book ID
110015629
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
142 KB
Volume
4
Category
Article
ISSN
1350-9047

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## Abstract Bcl‐2 family members are the arbiters of mitochondrial apoptotic pathway, which is conserved through evolution. The stoichiometry of pro‐ versus antiapoptotic Bcl‐2 family members in the cell determines whether the cell lives or dies. This fine balance is regulated at the transcriptiona