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The base excision repair: mechanisms and its relevance for cancer susceptibility

✍ Scribed by P Fortini; B Pascucci; E Parlanti; M D’Errico; V Simonelli; E Dogliotti

Book ID: 116308267
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 461 KB
Volume: 85
Category: Article
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2003.11.003

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## Abstract Oxidative damage represents the most significant insult to organisms because of continuous production of the reactive oxygen species (ROS) in vivo. Oxidative damage in DNA, a critical target of ROS, is repaired primarily via the base excision repair (BER) pathway which appears to be the