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The autoderivatization of 4-ketocyclophosphamide during capillary gas chromatography

✍ Scribed by de Bruijn, E. A. ;Leclercq, P. A. ;Tjaden, U. R.

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 407 KB
Volume: 9
Category: Article
ISSN: 0935-6304
DOI: 10.1002/jhrc.1240090207

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✦ Synopsis

The selectivity of a capillary gas chromatographic assay for the anti-neoplastic and immunosuppressive agent cyclophosphamide (CPA) towards one of its naturally occurring metabolites, i.e. 4-ketocyclophosphamide (4-keto CPA), has been studied. Mass spectrometry studies showed that a cyclization product of 4-keto-CPA can form using the same chromatographic conditions as t hose under which CPA was determined. However, the amount produced is relatively small (less than 10%) compared with the percentage produced from CPA. Furthermore, both cycliration products, formed by lossof HCI and intraalkylation of the parent compounds,can beseparated well under suitable chromatographic conditions.

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