The Aurora kinases: Role in cell transformation and tumorigenesis
β Scribed by Hiroshi Katayama; William R. Brinkley; Subrata Sen
- Book ID
- 110440525
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 985 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0167-7659
No coin nor oath required. For personal study only.
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## Abstract Activating __ras__ mutations are frequently found in malignant tumors of the pancreas, colon, lung and other tissues. RAS activates a number of downstream pathways that ultimately cause cellular transformation. Several recent studies suggested that one of those pathways involves Aurora
## Abstract **Background:** Various mitotic events are controlled by Cdc2βcyclin B and other mitotic kinases. Aurora/Ipl1βrelated mitotic kinases were proved to play key roles in mitotic progression in diverse lower organisms. AuroraβA is a mammalian counterpart of aurora/Ipl1βrelated kinases and i
## Abstract The Aurora kinases are involved in the regulation of cell cycle progression, and alterations in their expression have been shown to associate with cell malignant transformation. In the present study, we demonstrated that human thyrocytes express all 3 Aurora kinases (A, B and C) at both