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The atypical PKCs in inflammation: NF-κB and beyond

✍ Scribed by Maria T. Diaz-Meco; Jorge Moscat


Book ID
114796053
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
472 KB
Volume
246
Category
Article
ISSN
0105-2896

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Atypical PKC ζ is activated by ceramide,
✍ YongMing Wang; M. Lamar Seibenhener; Michel L. Vandenplas; Marie W. Wooten 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB 👁 1 views

Both protein kinase C (PKC) and ceramide play a critical role in cell signaling, but the relationship between PKC and ceramide is unclear. Low concentrations of ceramide were observed to transiently stimulate PKC activity in vitro and in vivo, whereas high doses of ceramide lead to inhibition of PKC