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PKCθ cooperates with atypical PKCζ and PKCι in NF-κB transactivation of T lymphocytes

✍ Scribed by Thomas Gruber; Friedrich Fresser; Marcel Jenny; Florian Überall; Michael Leitges; Gottfried Baier


Book ID
116756433
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
886 KB
Volume
45
Category
Article
ISSN
0161-5890

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Atypical PKC ζ is activated by ceramide,
✍ YongMing Wang; M. Lamar Seibenhener; Michel L. Vandenplas; Marie W. Wooten 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB 👁 1 views

Both protein kinase C (PKC) and ceramide play a critical role in cell signaling, but the relationship between PKC and ceramide is unclear. Low concentrations of ceramide were observed to transiently stimulate PKC activity in vitro and in vivo, whereas high doses of ceramide lead to inhibition of PKC