The asymmetric cyclohexenylation of 2,2-dimethyl-2,3-dihydrofuran

✍ Scribed by Alan J Hennessy; Yvonne M Malone; Patrick J Guiry

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 154 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00143-x

✦ Synopsis

The palladium catalysed asymmetric cyclohexenylation of 2,2-dimethyl-2,3-dihydrofuran is described. Use of this substrate allowed for an easy and direct comparison of a range of ligands in this reaction. The ligands employed included BINAP and phosphinamines and enantioselectivities of up to 97% were obtained with tert-leucinolderived diphenylphosphinoaryloxazolines.