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The Asymmetric Baylis−Hillman Reaction

✍ Scribed by Brzezinski, Linda Joy; Rafel, Sara; Leahy, James W.


Book ID
120563826
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
144 KB
Volume
119
Category
Article
ISSN
0002-7863

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N-Methylprolinol Catalysed Asymmetric Ba
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## Abstract __N__‐methylprolinol is used as a chiral base catalyst for the Baylis–Hillman reaction to obtain the adducts in good yields with moderate to good enantioselectivities in 1,4‐dioxane:water (1 : 1, v/v) under ambient conditions.

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## Abstract A chiral diamine, easily prepared from proline, is an effective, asymmetric organic catalyst for the Baylis–Hillman reaction of aldehydes and methyl vinyl ketone, affording adducts with enantioselectivities up to 75%.