𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The asymmetric addition of trimethylsilylcyanide to aldehydes catalysed by anionic chiral nucleophiles. Part 1

✍ Scribed by Ian P Holmes; Henri B Kagan

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
87 KB
Volume
41
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Trimethylsilylcyanide has been added to a number of aldehydes using a highly active chiral catalyst. This procedure gives the TMS ethers of the corresponding cyanohydrins in excellent chemical yields with enantiomeric excesses of up to 59%. The reaction is believed to occur through hypervalent silicon intermediates.

πŸ“œ SIMILAR VOLUMES

The asymmetric addition of trimethylsily
The asymmetric addition of trimethylsilylcyanide to aldehydes catalysed by anionic chiral nucleophiles. Part 2
✍ Ian P Holmes; Henri B Kagan πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 86 KB

Studies have been carried out on the addition of trimethylsilylcyanide to aldehydes using highly active chiral lithium phenolate catalysts. The screening of a number of chiral phenolates has resulted in a system which gives the TMS ethers of cyanohydrins in excellent chemical yields with enantiomeri

The asymmetric addition of trimethylsily
The asymmetric addition of trimethylsilyl cyanide to ketones catalysed by a bimetallic, chiral (salen)titanium complex
✍ Yuri N Belokon; Brendan Green; Nicolai S Ikonnikov; Michael North; Vitali I Tara πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 217 KB

The use of a bimetallic titanium salen complex as a catalyst for the asymmetric addition of trimethylsilylcyanide to ketones is reported. The cyanohydrin trimethyisilyl ethers are obtained with enantiomeric excesses of up to 72% from reactions carried out at room temperature and atmospheric pressure