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The association of α-actinin with the plasma membrane

✍ Scribed by Burridge, Keith ;McCullough, Lois

Publisher
Wiley (John Wiley & Sons)
Year
1980
Tongue
English
Weight
920 KB
Volume
13
Category
Article
ISSN
0091-7419

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✦ Synopsis

Abstract

The role of α‐actinin in the attachment of actin to plasma membranes has been investigated. Specific antibody staining of SDS gels has indicated that α‐actinin is a major component in isolated plasma membranes prepared from three different cell types by two different procedures. Using specific extraction conditions, most of the α‐actinin can be selectively extracted from the membranes with relatively little parallel release of actin. This selective dissociation of α‐actinin from the plasma membrane leads us to conclude that α‐actinin is present in these membrane preparations, because it is bound to actin, and that α‐actinin does not form a direct link between actin and the membrane.

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