𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The assessment of fractional drug removal by extracorporeal dialysis

✍ Scribed by Ching-San C. Lee

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
396 KB
Volume
3
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

It is generally concurred that the effectiveness of extracorporeal dialysis is best evaluated by fractional drug removal, i.e. the proportion of body burden of drug removed during the period of dialysis treatment. Two equations reported in the literature and five equations proposed in this article are examined for their validity in the assessment of fractional drug removal. Potential limitations and applicable conditions of these equations are discussed and compared. Calculations of fractional drug removal are demonstrated using both simulated and experimental data of ethambutol. Depending on the available kinetic measurements during dialysis and post dialysis, one may apply each equation separately or in conjunction with others to the calculation of fractional drug removal.

πŸ“œ SIMILAR VOLUMES

The removal of hepatitis B virus from fa
The removal of hepatitis B virus from factor VIII concentrates by fractionation on ethylene maleic anhydride polyelectrolyte
✍ S. A. Galpin; P. Karayiannis; S. M. Middleton; H. C. Thomas πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 301 KB

Chromatography with a solid-phase polyelectrolyte based on ethylene maleic anhydride polyelectrolyte (EMA PE) has been shown to remove a large proportion of hepatitis B surface antigen (HBsAg), including hepatitis B virus (HBV) particles, from contaminated cryoprecipitate. This process may reduce th

S-phase fraction assessed by a variant o
S-phase fraction assessed by a variant of the rectangular model adapted to the flow-cytometric DNA histogram profile
✍ Olle StΓ₯l; Bo Baldetorp πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 68 KB

## Measurement of S-phase fraction by DNA flow cytometry is widely used in the analysis of human tumors. The calculation of fraction of S-phase cells is performed either by means of curve-fitting techniques or by more simple planimetric methods. Estimates by the latter often suffer from subjectivi