Short-term and long-term modulation of g
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Peter Sazani; Marla M Vacek; Ryszard Kole
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Article
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2002
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Elsevier Science
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English
β 64 KB
To achieve effective modulation of gene expression by antisense oligonucleotides, novel oligonucleotide chemistries that do not promote RNase H degradation of target RNA are needed. In addition to short-term oligonucleotide effects, long-term gene regulation can be accomplished by intracellularly ex