Short-term and long-term modulation of gene expression by antisense therapeutics

✍ Scribed by Peter Sazani; Marla M Vacek; Ryszard Kole

• Book ID: 104361686
• Publisher: Elsevier Science
• Year: 2002
• Tongue: English
• Weight: 64 KB
• Volume: 13
• Category: Article
• ISSN: 0958-1669
• DOI: 10.1016/s0958-1669(02)00366-x

✦ Synopsis

To achieve effective modulation of gene expression by antisense oligonucleotides, novel oligonucleotide chemistries that do not promote RNase H degradation of target RNA are needed. In addition to short-term oligonucleotide effects, long-term gene regulation can be accomplished by intracellularly expressed antisense RNAs delivered by viral vectors.