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The ARF Tumor Suppressor Can Promote the Progression of Some Tumors

✍ Scribed by Humbey, O.; Pimkina, J.; Zilfou, J. T.; Jarnik, M.; Dominguez-Brauer, C.; Burgess, D. J.; Eischen, C. M.; Murphy, M. E.


Book ID
121748024
Publisher
American Association for Cancer Research
Year
2008
Tongue
English
Weight
500 KB
Volume
68
Category
Article
ISSN
0008-5472

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## Abstract The INK4b‐ARF‐INK4a locus encodes two members of the INK4 family of cyclin‐dependent kinase inhibitors, p15^INK4b^ and p16^INK4a^, and a completely unrelated protein called ARF. ARF is a nucleolar protein with unusual structure that exhibits tumor suppressive functions. There is growing