The application of unsymmetrical vinylogous iminium salts and related synthons to the preparation of monosubstituted triazolo [1, 5-a]pyrimidines
β Scribed by Scott A. Petrich; Zhenrong Qian; Lisa M. Santiago; John T. Gupton; James A. Sikorski
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 763 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4020
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π SIMILAR VOLUMES
The reaction of 1-substituted vinamidinium sails with sarcosine ethyl ester produced 2,3-disubstituted pyrroles; a similar reaction with glycine ethyl ester gave 2,5-disubstituted pyrroles. Reactions of related thr~--carbon synthons with sarcosinΒ’ and glycine were studied under basic, neutral and ac
Numerous novel pyrrole containing marine natural products have been shown to possess interesting biological properties These. compaunds have been the synthetic targets of several research groups and we have previously reported synthetic methods which utilize vinylogous iminium salt derivatives as bu
## Abstract This paper describes the preparation of some pyrazolo[1,5β__a__]β, 1,2,4βtriazolo[1,5β__a__]β and imidazo[1,2β__a__]βpyrimidines substituted on the pyrimidine moiety by a 4β[(__N__βacetylβ__N__βethyl)amino]phenyl group. A new synthesis of related benzo[__h__]pyrazolo[1,5β__a__]β, benzo[