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The application of equilibrium dialysis to the determination of drug-cyclodextrin stability constants

โœ Scribed by Sydney O. Ugwu; Marcos J. Alcala; Rend Bhardwaj; James Blanchard

Publisher
Springer Netherlands
Year
1996
Tongue
English
Weight
220 KB
Volume
25
Category
Article
ISSN
0923-0750

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## Synopsis A theoretical basis for thin-film dialysis involving binding between a ligand and nondialyzing species is presented. A general differential equation that applies to the case of equivalent, noninteracting sites is derived relating [A]F, [A]T, [PIT, and K . Numerical solutions to this eq

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An analysis of the kinetic identifiability of two-state excited-state processes gives the conditions which have to be fulfilled to make it possible to estimate the ground-state equilibrium constant from dynamic fluorescence data. For the aqueous system [3-cyclodextrin:pyrene it turns out that the on