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The application of allometric scaling principles to predict pharmacokinetic parameters across species

โœ Scribed by Huang, Qingbiao; Riviere, Jim E


Book ID
126917868
Publisher
Informa plc
Year
2014
Tongue
English
Weight
532 KB
Volume
10
Category
Article
ISSN
1742-5255

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Pharmacokinetic allometric scaling of an
โœ Iftekhar Mahmood ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 140 KB ๐Ÿ‘ 1 views

The objectives of this study are: (i) to evaluate the predictive performance of interspecies scaling for antibodies to predict clearance, volume of distribution at steady state, and half-life in humans from animal data and (ii) to estimate first-inhuman dose based on the predicted human clearance. F