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Application of allometric principles for the prediction of pharmacokinetics in human and veterinary drug development

โœ Scribed by Iftekhar Mahmood


Book ID
113418151
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
277 KB
Volume
59
Category
Article
ISSN
0169-409X

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โœ Huadong Tang; Michael Mayersohn ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 186 KB

Allometrically scaled data sets (138 compounds) used for predicting human clearance were obtained from the literature. Our analyses of these data have led to four observations. (1) The current data do not provide strong evidence that systemic clearance (CL(s); n = 102) is more predictable than appar