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The antitumor drug, 1,3-bis(2-chloroethyl)-1-nitroso-urea, inactivates human nicotinamide mononucleotide adenylyltransferase

✍ Scribed by Monica Emanuelli; Nadia Raffaelli; Adolfo Amici; Enrico Balducci; Paolo Natalini; Silveri Ruggieri; Giulio Magni

Book ID: 115783705
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 454 KB
Volume: 49
Category: Article
ISSN: 0006-2952
DOI: 10.1016/0006-2952(94)00478-5

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## Abstract A transient alkalosis of similar magnitude to that observed __in vivo__ has been observed using ^31^P NMR and 2‐deoxy‐D‐glucose‐6‐phosphate as a pH marker in a human glioma cell line, SKI‐1, with demonstrated sensitivity to 1, 3‐bis (2‐chloroethyl)‐1‐nitrosourea. At an effective dose of