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The antitumor agent mitoxantrone binds cooperatively to DNA: evidence for heterogeneity in DNA conformation

✍ Scribed by Rosenberg, Leonard S.; Carvlin, Mark J.; Krugh, Thomas R.


Book ID
120624826
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
880 KB
Volume
25
Category
Article
ISSN
0006-2960

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Theoretical evidence for the coupling of
✍ Gerald S. Manning πŸ“‚ Article πŸ“… 1981 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 862 KB

## Abstract Published data indicate linear variation of the duplex winding of DNA with logarithm of the ionic strength. We show that this observation is a natural prediction of a current poly‐electrolyte theory if structural coupling between duplex rotation angle (rotation per base pair) and step h