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Evidence for the Involvement of a Nitrenium Ion in the Covalent Binding of Nitrofurazone to DNA

✍ Scribed by Anthony J. Streeter; Betty-ann Hoener


Book ID
114421185
Publisher
Springer US
Year
1988
Tongue
English
Weight
459 KB
Volume
05
Category
Article
ISSN
0724-8741

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The primary mode of non-covalent interaction of the strong carcinogen, benzo(a)pyrene diol epoxide, with DNA is through intercalation. It has variously been suggested that intercalative complexes may be prerequisite for either covalent binding or DNA-catalysed hydrolysis of the epoxide or both. Geac