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The antitumor agent, 1,3-bis(2-chloroethyl)-1-nitrosourea

✍ Scribed by Ti Li Loo; Robert L. Dion; Robert L. Dixon; David P. Rall

Publisher: John Wiley and Sons
Year: 1966
Tongue: English
Weight: 539 KB
Volume: 55
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600550509

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📜 SIMILAR VOLUMES

Colorimetric method for the determinatio

Colorimetric method for the determination of 1,3-bis(2-chloroethyl)-1-nitrosourea

✍ Ti Li Loo; Robert L. Dion 📂 Article 📅 1965 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB

The ready liberation of nitrous acid by 1,3bis (2-chloroethyl)-l-nitrosourea in hydrochloric acid solution has been utilized successfully in the development of a sensitive colorimetric method for its quantitative estimation in biological fluids. 1,3-Bis(2-chloroethyl)-l-nitrosourea (BCNU), a novel

Fatal pulmonary fibrosis following 1,3-b

Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy

✍ Dr. C. C. Bailey; H. B. Marsden; P. H. Morris Jones 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 689 KB

Pulmonary fibrosis: A complication of 1,

Pulmonary fibrosis: A complication of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy

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Physiologic disposition of 1-(2-chloroet

Physiologic disposition of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (MeCCNU) in man

✍ Robert W. Sponzo; Vincent T. Devita; Vincent T. Oliverio 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 English ⚖ 466 KB 👁 2 views

The physiologic disposition of radioactive-labelled CCNU and MeCCNU was studied in patients receiving these drugs as part of their early clinical trial. CCNU was given orally in doses of 30-100 mg/m2 a n d MeCCNU in doses of 120-290 mg/m?. With both drugs, significant plasma levels of radioactivity

1,-(2-chloroethyl)-3-cyclohexyl-1-nitros

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Multiple pulmonary lesions in a patient

Multiple pulmonary lesions in a patient treated with BCNU (1,3-BIS(2-chloroethyl)-1-nitrosourea) for glioblastoma multiforme

✍ Peter A. Bellot; Ronald O. Valdiserri 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 568 KB

A patient with a glioblastoma multiforme who was treated with BCNU, developed rapidly progressive pulmonary disease. The pulmonary changes were studied pathologically and included atypical alveolar cell hyperplasia, hyaline membranes, and interstitial fibrosis. These lesions contributed to the patie