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Colorimetric method for the determination of 1,3-bis(2-chloroethyl)-1-nitrosourea

✍ Scribed by Ti Li Loo; Robert L. Dion

Publisher: John Wiley and Sons
Year: 1965
Tongue: English
Weight: 197 KB
Volume: 54
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600540538

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✦ Synopsis

The ready liberation of nitrous acid by 1,3bis (2-chloroethyl)-l-nitrosourea in hydrochloric acid solution has been utilized successfully in the development of a sensitive colorimetric method for its quantitative estimation in biological fluids.

1,3-Bis(2-chloroethyl)-l-nitrosourea (BCNU), a novel type of cancer chemotherapeutic agent. has shown marked activity against experimental neoplasms, especially intracerebral mouse leukemia ( 1).

Its possible usefulness in meningeal leukemia and brain tumors has been advocated. Clinical trial of this agent is currently in progress (2). In addition, BCNU is a potent inhibitor of several microorganisms (3). This paper describes a sensitive method for the quantitative determination of BCNU in biological fluids.

Being a derivative of a nitrosamide, BCNU decomposes in an excess of strong hydrochloric acid into nitrous acid and most likely 1,3-bis(2-chloroethyl)urea, the reversal of its mode of formation

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