β Scribed by Chandy, Thomas ;Sharma, Chandra P.
No coin nor oath required. For personal study only.
For intravascular implantation, a biofunctional surface seems to retard surface thrombosis upon synthetic materials.
Prostaglandins, like PGI,, PGE,, and PGD,, etc., are believed to stimulate membrane-bound adenyl cyclase and thereby raise intracellular levels of c-AMP within platelets, which inhibit platelet adhesion and aggregation. A new procedure is suggested for the immobilization of prostaglandin El on an albuminated polymer matrix, through glutaraldehyde coupling. Materials thus prepared show dramatic antiplatelet effects, with regard to platelet adhesion, when compared with albuminimmobilized surfaces. The affinity of various modified surfaces toward platelet adhesion is studied, using washed plate-lets suspended in Tyrode's solution. Octane contact angle studies are used to develop an understanding of the varied nature of bound substrates at equilibrium on polymer surfaces. These are studied at the solid/liquid interface, which is closest to in uiuo conditions. The plasma recalcification time demonstrates the anticoagulant properties of various surfaces. A possible role of PGE, in reducing platelet activity in the presence and absence of vitamin C is discussed. This technique may be used in the development of nonthrombogenic surfaces on existing biomedical polymers. Simultaneous pharmaceutical modification of the blood with vitamin C may enhance the blood compatibility of the surface.
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Prostaglandin E1 (PGE1) is a bronchodilator in humans, but the effect of this prostaglandin on airway responsiveness in asthmatic subjects is not known. The purpose of this study was to examine the effect of oral PGE1 treatment on airway responsiveness to inhaled histamine and methacholine in asthma
The effect of a polymer matrix on phase transitions in CuFe 2 O 4 spinel oxide has been studied. XRD results show that cubic CuFe 2 O 4 is obtained by quenching from 1173 K, while with CuFe 2 O 4 -PEEK composite samples, the cubic form is obtained by quenching from considerably lower temperatures (:
The liver has been judged relatively resistant to ischemia, but prolonged inflow occlusion at normothermic conditions can produce evidence of reversible or irreversible hepatocellular damage. Cytoprotective agents have been used both experimentally and clinically to afford extended viability of hepa