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The antipyretic effect of polymyxin B in endotoxin-induced fever

✍ Scribed by Miert, A. S. J. P. A. M. ;Duin, C. Th. M.

Publisher
Springer-Verlag
Year
1977
Weight
275 KB
Volume
1
Category
Article
ISSN
0378-4312

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Fever was induced in rats with a single i.p. injection of 30 g/kg E. coli endotoxin. The effect of the alcohol leaf extract of Azadirachta indica was investigated in this model. Pretreatment of rats with the leaf extract (125-375 mg/kg) did not significantly reduce endotoxin-induced fever. The recta